Congenital true leukonychia totalis

B. M. Vyshak, Snehal B. Lunge


Congenital true leukonychia totalis is very rare hereditary condition characterized by milky white discoloration of all nails. It has mainly autosomal dominant mode of inheritance and autosomal recessive in few cases. It may be inherited or associated with systemic disease or idiopathic. It has been linked to the mutations in PLCD1 gene on chromosome 3p21.3-p22. Leukonychia totalis is associated with multiple systemic diseases such as congenital hyperparathyroidism, Hodgkin's lymphoma, Leopard syndrome, Epiphyseal dysplasia syndrome, Bart Pumphrey syndrome etc. we report a case of sporadic congenital leukonychia totalis in a 24 years female without any systemic abnormalities.


Congenital leuconychia, Leukonychia totalis, White nails, Partial leukonychia

Full Text:



Ganesh A, Priyanka G. Idiopathic congenital true leukonychia totalis. Indian Dermatol Online J. 2014;5(1):65-6.

Pakornphadungsit K, Suchonwanit P, Sriphojanart T, Chayavichitsilp P. Hereditary Leukonychia Totalis Case Rep Dermatol. 2018;10:82-8.

Angoori GR, Koppada D. Idiopathic total leukonychia involving fingernails: A report of two cases. Arch Med Health Sci. 2015;3:302-5.

Das A, Bandyopadhyay D, Podder I. Idiopathic acquired true leukonychia totalis. Indian J Dermatol. 2016;61:127.