DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20201577

Splash mask formulation of tangerine (Citrus reticulata Blanco.) peel extract and turmeric (Curcuma longa L) extract as a whitening agent

Framesti Frisma Sriarumtias, Nurul Auliasari

Abstract


Background: Indonesia is a tropical country that is exposed to the sun for 12 hours, one of the harm effects of sunlight which is damage to the skin. The purpose of this study was to determine tyrosinase inhibition of tangerin peel extract (Citrus reticulata Blanco.) from Garut, West Java, Indonesia then develop the splash mask from the extract.

Methods: The tangerine peel will be extracted by maceration method. The splash mask formulation containing tangerine peel extract which has a whitening agent. Tyrosinase inhibition determine by ELISA method with tyrosinase enzyme and L-DOPA substrat.

Results: The results showed that tangerine peel extract had tyrosinase inhibition with the IC50 of 30.000 ppm, which has less effective than kojic acid with IC50 81,10 ppm. Splash mask containing of 1000x IC50, evaluation carried out for 28 days showed that preparations made pharmaceutically stable.

Conclusions: In addition, the whitening agent of tangerine peel extract is in the weak category. It is hoped that this research can increase the value of tangerine peel waste.

 


Keywords


Splash mask, Tangerines peel extract, Tyrosinase, Whitening agent

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References


Vashi NA, Kundu RV. Facial hyperpigmentation: Causes and treatment. Br J Dermatol. 2013;169(3):41-56.

Davis EC, Callender VD. A Review of the Epidemiology, Clinical Features, and Treatment Options in Skin of Color. J Clin Aestetic Dermatology. 2010;3(7):20-31.

Desai SR, Alexis A. Hyperpigmentation therapy: A review. J Clin Aesthet Dermatol. 2014;7(8):13-7.

Hollinger JC, Angra K, Halder RM. Are natural ingredients effective in the management of hyperpigmentation: a systematic review. J Clin Aesthet Dermatol. 2018;11(2):28-37.

Mirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z, Sahebkar A. Review: Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother [Internet]. 2017;85:102-12.

Hasan H, Rasyid ADAD, Ririn. Development Formulation of Lemon Syrup (Citrus limon L.) in Facial Peeling Scrub with Variation Concentration of Tea-Stearate. J Pharm Med Sci. 2017;2(2):63-7.

Tumbas VT, Cetkovic GS, Djilas SM, Canadanovic-Brunet JM, Vulic JJ, Knez Z, et al. Antioxidant activity of mandarin (citrus reticulata) peel. Acta Period Technol. 2010;41:195-203.

AS, AH, Prakash HL. Pharmacological activities of wild turmeric (Curcuma aromatica Salisb): a review. J Pharmacogn Phytochem. 2015;3(5):1-4.

Sriarumtias FF, Nafisah FN, Gozali D. Splash Mask Formulation of Tangerine (Citrus reticulata Blanco.) Peel extract as an antixodant. J Ilm Farm Bahari. 2019;10(2):205-19.

Sriarumtias FF, Najihudin A, Putri IR, Akmal A, Hamdani S. Microemulgel formulation of Kepok banana peel extract (Musa paradisiaca L) as an antioxidant. J Phys Conf Ser. 2019;1402(5):1-7.

Sriarumtias FF. Measurment of betacharotene and phenol levels of yellow Pepino Fruit (Solanum muricatum Aiton) at diverent maturity levels. J Farm Bahari [Internet]. 2016;7(2):12-21.

Mukherjee PK, Biswas R, Sharma A, Banerjee S, Biswas S, Katiyar CK. Validation of Medicinal Herbs for Anti-tyrosinase Potential Pulok. J Herb Med. 2018;09(002):1-60.

Piao LZ, Park HR, Park YK, Lee SK, Park JH, Park MK. Mushroom tyrosinase inhibition activity of some chromones. Chem Pharm Bull. 2002;50(3):309-11.

Hindun S, Rusdiana T, Abdasah M, Hindritiani R. Potency of Lemon Peel (Citrus auronfolia) waste as tirosinase inhibitor. Indones J Pharm Sci Technol. 2017;4(2):64.

Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipient. Vol. 6. Pharmaceutical Press; 2009: 283-286.

Selvi S. The Effect of Concentration of DMDM Hydantion reserve on Characteristics, Physical stability and pH on water based Pomade containing aloe vera extract. Calyptra J Ilm Mhs Univ Surabaya. 2017;6(2):553-66.

Sriarumtias FF, Tarini S, Damayanti S. Retinyl Palmitate Nanostructured Lipid Carrier (NLC) Formulation and antioxidant potential test. Acta Pharm Indones. 2017;42(1):25-31.

Najihudin A, Sriarumtias FF, Rantika N, Sutrisna IW. Development of Antioxidant Gel from Green Grass Jelly Leaf (Premna Oblongata Miq). J Farm Galen. 2019;6(3):125-34.

Masamoto Y, Ando H, Murata Y, Shimoishi Y, Tada M, Takahata K. Mushroom tyrosinase inhibitory activity of esculetin isolated from seeds of euphorbia lathyris L. Biosci Biotechnol Biochem. 2003;67(3):631-4.

Fais A, Corda M, Era B, Fadda MB, Matos MJ, Quezada E, et al. Tyrosinase inhibitor activity of coumarin-resveratrol hybrids. Molecules. 2009;14(7):2514-20.