Evaluation of newer imidazoles in dermatophytosis

Authors

  • Annie Ratnam Nakka Department of Dermatology, Venereology and Leprology, Bhaskar Medical College, Yenkapally, Moinabad, Ranga Reddy District, Hyderabad, Telangana, India
  • Janardhan Bommakanti Department of Dermatology, Venereology and Leprology, Bhaskar Medical College, Yenkapally, Moinabad, Ranga Reddy District, Hyderabad, Telangana, India
  • Siva Rami R. Karumuri Department of Dermatology, Venereology and Leprology, Bhaskar Medical College, Yenkapally, Moinabad, Ranga Reddy District, Hyderabad, Telangana, India
  • Naresh B. Thambisetti Department of Dermatology, Venereology and Leprology, Bhaskar Medical College, Yenkapally, Moinabad, Ranga Reddy District, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20195677

Keywords:

Dermatophytosis, Tinea corporis, Tinea cruris, Eberconazole, Sertaconazole, Luliconazole

Abstract

Background: Eberconazole, a newer Imidazole derivative, antimycotic drug. Similarly, sertaconazole and luliconazole are also newer antifungal which all exhibit fungicidal, fungistatic and anti-inflammatory actions. But, sertaconazole in addition have antipruritic effect also.

Methods: Randomized, open-labelled, prospective study comprising of 75 patients divided into three equal groups A, B, C of 25 patients each. Group A received eberconazole 1%, Group B received sertaconazole 2% and Group C received luliconazole 1% for twice daily topical application for 4 weeks. Patients were asked to review at 2nd and 4th week to record clinical and mycological cure.

Results: In this study out of 75, seventy patients completed the complete course of treatment whereas, five patients were not reported for review citing personal reasons. Parameters included are pruritus, erythema, scaling and vesicles in all three groups. In this study, marked relief of pruritus was achieved clinically with eberconazole (72.7%) followed by luliconazole and sertaconazole with 50.0% and 33.3% respectively at 4th week of treatment phase and reduction of scaling was achieved more with eberconazole (90.9%), sertaconazole (87.5%) and luliconazole (83.3%). All three groups of patients showed successful mycological cure by confirming with negative 10% potassium hydroxide examination at the end of treatment course.

Conclusions: Eberconazole 1% cream was better than sertaconazole 2% cream and luliconazole 1% cream in relieving symptoms like pruritus and scaling at the end of treatment phase and follow up.

References

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Published

2019-12-23

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Original Research Articles