DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20194686

Bleomycin-induced flagellate pigmentation: a case report from North-East India

Nandakishore Thokchom, Nandita Bhattacharjee, Linda Kongbam

Abstract


Bleomycin is an antitumour antibiotic commonly used in the management of Hodgkin’s lymphoma and germ cell tumours. Flagellate pigmentation is a very specific and rare cutaneous adverse effect of bleomycin. It is characterised by linear, painless, pruritic, hyperpigmented lesions simulating marks of whiplashes over trunk and extremities. With the advent of targeted therapies resulting in the infrequent use of bleomycin, this unique side effect is also uncommonly encountered nowadays. Here, we report a case of bleomycin-induced flagellate pigmentation in a 35-year-old Indian female with ovarian teratoma. The characteristic patterned hyperpigmented patches developed following 2nd cycle of chemotherapy with bleomycin, etoposide and cisplatin.

 


Keywords


Bleomycin, Flagellate, Pigmentation

Full Text:

PDF

References


Moulin G, Fiere B, Beyvin A. Cutaneous pigmentation caused by bleomycin. Bull Soc Fr Dermatol Syphiligr. 1970;77:293-6.

Chang MW. Disorders of hyperpigmentation. In: Bolognia JL, Schaffer JV, Cerroni L, editors. Dermatology. 4th ed. China: Elsevier Limited; 2018: 1115-1143.

Vuerstaek JD, Frank J, Poblete-Gutierrez P. Bleomycin-induced flagellate dermatitis. Int J Dermatol. 2007;46(3):3-5.

Grynszpan R, Niemeyer-Corbellini JP, Lopes MS, Ramos-e-Silva M. Bleomycin-induced flagellate dermatitis. BMJ Case Rep. 2013;2013:bcr2013009764.

Sharma P, Sinha R, Kumar D, Kumar A. Bleomycin-induced flagellate dermatosis in a 7-Year-Old child: A case report with review of literature. Indian J Paediatr Dermatol. 2018;19:339-41.

Abess A, Keel DM, Graham BS. Flagellate hyperpigmentation following intralesional bleomycin treatment of verruca plantaris. Arch Dermatol. 2003;139:337-9.

Cohen PR. Trastuzumab-associated flagellate erythema: Report in a woman with metastatic breast cancer and review of antineoplastic therapy-induced flagellate dermatoses. Dermatol Ther. 2015;5:253-64.

Gaurkar SP, Mehta N, Parmar KS, Shah BJ. Bleomycin-induced flagellate dermatitis. Indian J Drugs Dermatol. 2015;1:38-40.

Basu D, Podder I, Das A. Bleomycin-induced flagellate hyperpigmentation: a case report with review of literature. Pigment Int. 2016;3:40-2.

Larson KN, Gagnon AL, Wilson BB. Bleomycin-induced flagellate hyperpigmentation. Clin Case Rep. 2017;5(4):429-30.