Generalized pigmentation with nutritional deficiency

Authors

  • Snahasish Naskar Department of Skin and V.D., Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India
  • Vidya Kharkar Department of Skin and V.D., Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20195687

Keywords:

Vitamin B12 deficiency, Generalized hyperpigmention, Addisonian

Abstract

Vitamin B12 deficiency is one of the most underdiagnosed causes of hyperpigmentation. It is known to cause Addisonian pigmentation. We describe a case where a patient presented with hyperpigmentation on the aesthetically significant areas of the body for which he presented to the clinic. Diagnosis was confirmed on histopathology and serum vitamin B12 levels. The hyperpigmentation reversed significantly on treatment.

References

Sen K, Sinhamahapatra P, Lalhmachhuana J, Ray S. A study of clinical profile of vitamin B 12 deficiency with special reference to dermatologic manifestations in a tertiary care hospital in sub-Himalayan Bengal. Indian J Dermatol. 2015;60(4):419.

Khanduri U, Sharma A. Megaloblastic anemia: prevalence and causative factors. Natl Med J India. 2007;4:172-5.

Agrawala RK, Sahoo SK, Choudhury AK, Mohanty BK, Baliarsinha AK. Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: a rare presentation. Indian J Endocr Metab. 2013;17:254-6.

Gupta AK, Damji A, Uppaluri A. Vitamin B12 deficiency. Prevalence among South Asians at a Toronto clinic. Can Fam Physician. 2004;50:743-7.

Aaron S, Kumar S, Vijayan J, Jacob J, Alexander M, Gnanamuthu C. Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes. Neurol India. 2005;53(1):55-8.

Gilliam JN, Cox AJ Epidermal changes in vitamin B 12 deficiency. Arch Dermatol. 1973;107(2):231-6.

Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington (DC): National Academies Press (US); 1998.

Ankar A, Kumar A. Vitamin B12 Deficiency (Cobalamin). Stat Pearls; 2019.

Leary FO, Samman S. Vitamin B12 in Health and Disease. Nutrients. 2010;2(3):299–316.

Wadia RS, Bandishti S, Kharche M. B12 and folate deficiency: incidence and clinical features. Neurol India. 2000;48:302-4.

Bernard M, Babior H, Franklin B. Megaloblastic anemias. In: Harrison's Principles of Internal Medicine. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, eds. 16th ed. McGraw-Hill: New York; 2005: 601-607.

Mori K, Ando I, Kukita A. Generalized hyperpigmentation of the skin due to vitamin B12 deficiency. AJ Dermatol. 2001;28(5):282-5.

Downloads

Published

2019-12-23