Published: 2019-07-24

Acute methotrexate toxicity in psoriasis

Peram Karunakar, Venkateswara Rao Garimella, Chinmai Yerram, Anusha Gogula


We describe two cases of low dose methotrexate (MTX) toxicity in patients with psoriasis. Patient was a 49-year-old male, known case of chronic plaque psoriasis from 10 years on and off. He was advised to take MTX 2.5 mg 2 days a week but patient took 2.5 mg twice daily (BD) for 6 continuous days following which he developed ulceration over psoriatic plaques and bone marrow suppression. MTX is safe and effective if adhered to standard treatment guidelines but inadverent use may lead to it’s toxicity.


Methotrexate, Psoriasis, Toxicity

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