Aggressive mycosis fungoides/sézary syndrome in Nigeria: case report and literature review

Authors

  • Oreoluwa Arowojolu College of Medicine, University of Ibadan, Ibadan, Nigeria; Lakeshore Cancer Center, Victoria Island, Lagos, Nigeria
  • Oluwasegun Afolaranmi College of Medicine, University of Ibadan, Ibadan, Nigeria; Lakeshore Cancer Center, Victoria Island, Lagos, Nigeria
  • Mutiu Jimoh Lakeshore Cancer Center, Victoria Island, Lagos, Nigeria; Department of Clinical and Radiation Oncology, University College Hospital, Ibadan, Nigeria

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20191773

Keywords:

Mycosis fungoides, Sézary syndrome, Cutaneous T-cell lymphomas, Nigeria, Africa

Abstract

Mycosis fungoides and its variant, sézary syndrome are rare neoplastic conditions which are part of a larger group of lymphomas that primarily affect the skin known as cutaneous T-cell lymphomas. We report a case of fatal aggressive mycosis fungoides/sézary syndrome in a 55-year old Nigerian man who initially developed pruritic hyperpigmented spots on his skin which progressed over the course of 5 years to widespread scaly mixed hyperpigmented and hypopigmented plaques and nodules with features of organ involvement despite being managed with Psoralen and ultraviolet A radiation (PUVA), total skin electron-beam (TSEB), local electron-beam radiation, bexarotene, and oral prednisolone and chlorambucil (Winklemann regimen). In the process, we highlight the rarity of the condition, its ease of misdiagnosis and its predilection for people of Sub-Saharan decent.

Author Biographies

Oreoluwa Arowojolu, College of Medicine, University of Ibadan, Ibadan, Nigeria; Lakeshore Cancer Center, Victoria Island, Lagos, Nigeria

Medical Student

Oluwasegun Afolaranmi, College of Medicine, University of Ibadan, Ibadan, Nigeria; Lakeshore Cancer Center, Victoria Island, Lagos, Nigeria

Medical Student

Mutiu Jimoh, Lakeshore Cancer Center, Victoria Island, Lagos, Nigeria; Department of Clinical and Radiation Oncology, University College Hospital, Ibadan, Nigeria

Consultant Clinical and Radiation Oncologist, Department of Clinical and Radiation Oncology

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Published

2019-04-26

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Section

Case Reports