A clinical study of cutaneous manifestations in renal transplant recipients

Authors

  • Pradeep Vittal Bhagwat Department of Dermatology, Venereology and Leparology, Karnataka Institute of Medical Sciences, Hubbali, Karnataka, India
  • R. Rajagopal Department of Dermatology, Command Hospital, Air Force, Bangalore, Karnataka, India
  • P. S. Murthy Department of Dermatology, Command Hospital, Air Force, Bangalore, Karnataka, India
  • R. S. V. Kumar Department of Medicine, Command Hospital, Air Force, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20190053

Keywords:

Transplantation, Fungal infections, Momomorphic acne

Abstract

Background: Chronic renal failure is becoming common entity with increased incidence of diabetes mellitus and resulting diabetic nephropathy. With the availability of renal transplantation services in many centers, increased availability of donors, improved surgical technique and availability of better drugs, the survival of renal transplant recipients has increased. The objective of the study was to study the cutaneous manifestations in renal transplant recipients.

Methods: Fifty consenting, consecutive renal transplant recipients attending the OPD and in-patients at Command Hospital Air Force, Bangalore during July 2001 to March 2003 were included in the study. Detailed history was taken and clinical examination was carried out with special emphasis on the Dermatological examination. Relevant investigations were carried out.

Results: A total of 50 renal transplant recipients were studied of which 42 (84%) were males and 8 (16%) were females. The age of patients ranged from 16 years to 60 years. Infections were the most common finding, encountered in 38 (76%) patients, followed by drug induced manifestations in 24 (48%) patients. Cellulitis was noted in 1 (2%) patient, viral infections were seen in 18 (36%) patients, fungal infection was the commonest in this study, encountered in 38 (76%) patients. Monomorphic acne was seen in 13 (26%) patients. Hypertrichosis/hirsutism were the commonest drug induced manifestation in this study, seen in 16 (32%) patients.

Conclusions: In patients with renal transplantation, superficial fungal infections and viral infections of the skin are seen more commonly. Monomorphic acne and hypertrichosis due to immunosuppressive are also seen frequently. These changes are moderately influenced by the immunosuppressive regimen used.

References

Brenner BM, Lazarus M. Chronic renal failure. Harrison’s principles of internal medicine, 15th edition: McGraw Hill Inc, 2000.

Gupta AK, Gupta MA, Cardella CJ, Haberman HF. Cutaneous associations of chronic renal failure and dialysis. Int J Dermatol. 1986;25:489-503.

Seckin D, Gulec TO, Demirag A, Bilgin AN. Renal transplantation and skin disease. Transplant Proceedings. 1998;30:802-4.

Euvrard S, Kanitakis J, Cochat P, Cambazard F, Claudy A. Skin diseases in children with organ transplants. J Am Acad Dermatol. 2001;44:932-9.

Koranda FC, Dehmel EM, Kahn G, Penn I. Cutaneous complications in immune-suppressed renal homograft recipients. J Am Med Assoc. 1974;229:419-24.

Lugo-Janer G, Sanchez JL, Santiago-Delpin E. Prevalence and clinical spectrum of skin disease in kidney transplant recipients. J Am Acad Dermatol. 1991;24:410-4.

Daley TD, Wysocki GP, Day C. Clinical and pharmacological correlations in cyclosporine induced gingival hyperplasia. Oral Surg Oral Med Oral Pathol. 1986;62:417.

Sheil AGR. In XIV Report of the Australia and New Zealand Combined Dialysis and Transplant Registry (A P S Disney, ed). The queen Elizabeth Hospital, Woodville, South Australia; 1991: 100.

Tessari G, Barba A. Excessive Number of skin cancers in an Italian Renal Transplant recipient. Nephron. 2000;84:183-4.

Downloads

Published

2019-01-25

Issue

Section

Original Research Articles