Study of dermatological manifestations amongst patients with chronic kidney disease

Authors

  • Manish Kadam Department of Skin and VD, Indian Institute of Medical Science and Research Medical College, Badanapur, Jalna, Maharashtra, India
  • Pranita Kadam Department of Physiology, MGM Medical College, Aurangabad, Maharashtra, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20184458

Keywords:

Hemodialysis, Dermatosis, Skin problems, Xerosis

Abstract

Background: The number of patients with end-stage renal disease (ESRD) in India is increasing with an estimated annual incidence of about 100 per million populations. Hemodialysis is one of the therapeutic modalities which can improve the survival in these patients. About 50–100% of patients with ESRD have at least one associated cutaneous change Skin problems are common and diverse in patients with chronic kidney disease (CKD), especially among those on hemodialysis. Objective was to study dermatologic manifestations among patients with chronic kidney disease on maintenance hemodialysis.

Methods: A descriptive observational study was conducted in 77 consecutive chronic kidney disease patients receiving maintenance hemodialysis for more than 3 months at Manik Hospital, Aurangabad, Maharashtra, India.

Results: Out of 77 patients, 51 (66.23) of males and 26 (23.67) of females were examined. Male: Female ratio was 1.96: 1. The mean age was 51.17±15.22 years. Seventy three (94.08) patients had at-least one skin manifestation. Xerosis was the commonest manifestation (87.01), followed by pruritus (57.14). Cutaneous infections were noted in 55.84% patients. Fungal infections were more common with 27.27%. Mild xerosis was noted in 55.84% patients, 24.67% patients were moderate and whereas severe xerosis was noted in 6.49% patients.

Conclusions: Chronic kidney disease patients have prolonged life expectancy due to hemodialysis, hence they should be looked for presence of various skin manifestations which can affect the usual work and cause sleep disturbance which adds to the morbidity and mortality.

Author Biography

Manish Kadam, Department of Skin and VD, Indian Institute of Medical Science and Research Medical College, Badanapur, Jalna, Maharashtra, India

Dept. of community medicine, IIMSR medical college, Badnapur, Jalna, Maharashtra

References

Incidence of Treatment for End-Stage Renal Disease Attributed to Diabetes Mellitus -United States, 1980-1989. MMWR Morb Mortal Wkly Rep. 1992;41:834-7.

Nunley JR. Dermatologic manifestations of renal disease. eMed J. 2009:550.

Pico MR, Lugo-Somolinos A, Sanchez JL, Burgos-Calderon R. Cutaneous alterations in patients with chronic renal failure. Int J Dermatol. 1992;31(12):860-3.

Lundin AP, Fani K, Berlyne GM, Friedman EA. Dermal angiopathy in hemodialysis patients: the effect of time. Kidney Int. 1995;47(6):1775-9.

Abdelbaqi-Salhab M, Shalhub S, Morgan MB. A current review of the cutaneous manifestations of renal disease. J Cutan Pathol. 2003;30:527–38.

Akhyani M, Ganji M-R, Samadi N. Pruritus in hemodialysis patients. BMC Dermatol. 2005;5:7-9.

Udayakumar P, Balasubramanian S, Ramalingam KS, Lakshmi C, Srinivas CR, Mathew AC. Cutaneous manifestations in patients with chronic renal failure on hemodialysis. Indian J Dermatol Venereol Leprol. 2006;72:119–25.

Narita I, Alchi B, Omori K, Sato F, Ajiro J, Saga D, et al. Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients. Kidney Int. 2006; 69:1626–32.

Pavel Dyachenko, Arshalom Shustak, Dganit Rozenman. Hemodialysis-related pruritus and associated cutaneous manifestations. Int J Dermatol. 2006;45:664-7.

Szepietowski JC, Sikora M, Kunsztal M, Salomon J, Magott M, Szepietowski T. Uremic pruritus: a clinical study of maintenance dialysis patients. J Dermatol. 2002;29:621-7.

Yosipovitch G, Reis J, Tur E. Sweat secretion, stratum corneum hydration, small nerve function and pruritus in patients with advanced chronic renal failure. Br J Dermatol. 1995;133(4):561-4.

Morton CA, Lafferty M, Hau C, Henderson I, Jones M and Lowe JG. Pruritus and skin hydration during dialysis. Nephrol Dial Transplant. 1996;11:2031-36.

Joseph Daisy, Papali Cynthia, Pisharody Ramadas, Kyrle's disease: a cutaneous marker of renal disorder. Indian J Dermatol Venereol Leprol. 1996;62(4):222-5.

Saray Y, Seçkin D, Bilezikçi B. Acquired perforating dermatosis: clinicopathological features in twenty-two cases. JEADV. 2006;20:679–88.

Singh G, Singh SJ, Chakrabarthy N, Siddharaju KS, Prakash JC. Cutaneous manifestations of chronic renal failure. Indian J Dermatol Venereol Leprol. 1989;55:167-9.

Remuzzi G. Bleeding in renal failure. Lancet. 1988;28:1205-08.

Barbara Gilcherest, John W. Rowe, Martin C. Mihm Jr. Bullous Dermatosis of Hemodialysis. Ann Int med. 1975;83(4):480-3.

Poh-Fitzpatrick MB, Masullo AS, Grossman ME. Porphyria cutanea tarda associated with chronic renal disease and hemodialysis. Arch Dermatol. 1980;116(2):191-4.

Glynne P, Deacon A, Goldsmith D. Bullous dermatoses in endstage renal failure: porphyria or pseudoporphyria? Am J Kidney Dis. 1999;34:155-60.

Lindsay RM, Briggs JD, Luke RG, Boyle IT, Kennedy AC. Gynecomastia in chronic renal failure. Br Med J. 1967;4:779-80.

Downloads

Published

2018-10-25

Issue

Section

Original Research Articles