DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20222066

A clinicopathological study on interface dermatitis

Vaishnavi R. Batchu, Vijaya L. Panthalla, P. V. Kiran Kumar, K. Penchalaiah

Abstract


Background: Diagnosis of skin disorders that exhibit interface dermatitis is challenging in few scenarios. Despite sincere efforts, clinical examination per se can help us reach a handsome of differential diagnosis but not a gunshot specific diagnosis. Dermatopathology acts as a saviour to clinicians in such cases. Though histopathology is the gold standard, still one cannot make a “specific” diagnosis by histopathology alone because many have overlapping features. Therefore, the present study aims at the importance of clinicopathological correlation. The objectives were to study the clinical and histopathological features of various dermatoses, which exhibit interface dermatitis histopathologically and estimate clinicopathological concordance.

Methods: This was a cross-sectional study done on 50 patients attending outpatient department (OPD), with the lesions suggestive of dermatoses known to exhibit interface dermatitis histologically. Strobe guidelines were followed. After a thorough clinical examination, punch biopsies were done and observed microscopically to detect interface dermatitis, if present. Secondary pathological features were studied to assess clinicopathological concordance. Microsoft excel and statistical package for the social sciences (SPSS) 21.0 were used for data analysis.

Results: 76.74% cases were cases of lichen planus and its variants. The most common clinical presentation was papules. Among microscopic features, predominant finding was basal cell vacuolar change in epidermis (97.70% cases). Clinicopathological concordance was seen in 43 cases (83%). 7 cases were diagnosed solely based on histological correlation.

Conclusions: A myriad of dermatoses exhibit interface dermatitis as a primary pathological feature. Only an apt correlation of clinical features with secondary pathological features can lead to a specific diagnosis from a bunch of differential diagnoses.


Keywords


Interface dermatitis, Lichen planus, Civatte bodies, Pigment incontinence

Full Text:

PDF

References


Attili SK. “Interface” Dermatoses: Revisited. Indian J Dermatopathol Diagnostic Dermatol. 2019;6(1):14.

Sontheimer RD. Lichenoid tissue reaction/ Interface dermatitis: Clinical and histological perspectives. J Investig Dermatol. 2009;129:1088-99.

Paul M. Clinicopathologic mimics of Lichenoid eruptions. Paper presented at MID DERMACON. 2020.

Sehgal VN, Rege VL. Lichen planus: an appraisal of 147 cases. Indian J Dermatol Venereol Leprol. 1974;40:104.

Kumar M, Yelikar BR, Inamadar AC, Umesh S, Singhal A, Kushtagi AV. A clinico-pathological study of lichenoid tissue reactions-a tertiary care experience. J Clin Diagnostic Res. 2013;7(2):312.

Sarin N, Anand P, Khurana V.K. Lichenoid tissue reactions- a study of various histomorphological patterns with clinical correlation and review of literature. Int J Rec Scientific Res. 2017;8(9):20409-15.

Manjunatha MR. Study Of Histopathological Spectrum Of Interface Dermatitis (Doctoral dissertation on the internet). Bangalore: Rajiv Gandhi University of Health Sciences digital repository. 2009. Available at: http://hdl.handle.net/ 123456789/1538. Accessed on 24 March 2022.

Chauhan R, Srinath MK, Ali NM, Bhat RM, Sukumar D. Clinicopathological study of lichenoid reactions: a retrospective analysis. J Evol Med Dent Sci. 2015;4(32):5551-64.

Pawar VR, Mane VP, Ashtekar RS. Spectrum of Interface dermatitis: An Observational study’. Ann Appl Bio-Sciences. 2017;4(2):104-10.

Dhar R, Gaikwad P, Sahai J, Sahu S. Histopathological Spectrum of Interface Dermatitis and Its Clinicopathological Correlation. Int J Health Sci Res. 2020;10(12):17-24.

Hegde VK, Khadilkar UN. A clinicopathological study of interface dermatitis. Indian J Pathol Microbiol. 2014;57(3):386.

Kumar RN. A clinical and histopathological study of lichen planus. Bangalore: Rajiv Gandhi University of Health Sciences digital repository. 2015. Available at: http://localhost:8080/xmlui/handle/123456789/ 36089. Accessed on 24 March 2022.

Kachhawa D, Kachhawa V, Kalla G, Gupta LP. A clinico-aetiological profile of 375 cases of lichen planus. Indian J Dermatol Venereol Leprol. 1995;61:276-9.

Dixit D, Vernekar SS, Giriyan SS. A clinico-pathological study of lichenoid tissue reactions/interface dermatitis. Int J Res Med Sci. 2019;7(4):1002-8.

Khaled A, Banu SG, Kamal M, Manzoor J, Nasir TA. A Clinical and Histopathological study of Lichenoid Eruption of Skin in Two Tertiary Care Hospitals of Dhaka. Pulse. 2011;5(1):12-8.

Parihar A, Sharma S, Bhattacharya SN, Singh UR. A clinicopathological study of cutaneous lichen planus. J Dermatol Dermatol Surg. 2015;19(1):21-6.

Banushree CS, Nagarajappa AH, Dayananda SB, Sacchidanand S. ClinicoPathological Study of Lichenoid Eruptions of Skin. J Pharm Biomed Sci. 2012;25(25):226-30.

Attili VR, Attili SK. Lichenoid inflammation in vitiligo–a clinical and histopathologic review of 210 cases. Int J Dermatol. 2008;47(7):663-9.

Sharquie KE, Mehenna SH, Nazi AA. Inflammatory changes in vitiligo. Stage I and stage II depigmentation. Am J Dermatopathol. 2004;26:108-12.

Hann SK, Park YK, Lee KG. Epidermal changes in active vitiligo. J Dermatol. 1992;19:217-22.

Montes LF, Abulafica J, Wilborn WH. Value of histopathology in vitiligo. Int J Dermatol. 2003;42:57-61.

Gokhale BB, Mehta LN. Histopathology of vitiliginous skin. Int J Dermatol. 1983;22:477-80.

Joshi R. Interface dermatitis. Indian J Dermatol Venereol Leprology. 2013;79(3):349.

LeBoit PE. Interface dermatitis: how specific are its histopathologic features?. Arc Dermatol. 1993;129(10):1324-8.