Bilateral symmetric Merkel cell carcinomas of the dorsal hands: multiple primary tumors or early metastasis?

Authors

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20213352

Keywords:

MCC, MCV, Neuroendocrine tumor, Cytokeratin-20

Abstract

Merkel cell carcinoma (MCC) is an aggressive and uncommon neuroendocrine tumor which clinically presents as a rapidly growing solitary nodule or plaque located in sun exposed areas on the head, neck, and extremities. Merkel cell carcinomas can be UV-induced or result from viral infection with the Merkel cell polyomavirus (MCV). We present a unique case of bilateral symmetric Merkel cell carcinomas located on the dorsal hands and briefly discuss options for genomic investigation to delineate if the tumors are multiple primary tumors or result of metastatic disease.

References

Coggshall K, Tello TL, North JP. Merkel cell carcinoma: An update and review: Pathogenesis, diagnosis, and staging. J Am Acad Dermatol. 2018;78(3):433-42.

Paulson KG, Park SY, Vandeven NA. Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics. J Am Acad Dermatol. 2018;78(3):457-63.e2.

Feng H, Shuda M, Chang Y. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319(5866):1096-100.

Kassem A, Schöpflin A, Diaz C. Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res. 2008;68(13):5009-13.

Church CD, Nghiem P. How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model. J Invest Dermatol. 2015;135(5):1221-4.

Weedon D. Neural and Neuroendocrine Tumors. Churchill Livingstone/Elsevier; 2010;884.

National Comprehensive Cancer Network. Merkel cell carcinoma. 2015. Avaialbe at: http://merkelcell.org/wp-content/uploads/2015/10/MccNccn.pdf. Accessed on February 6, 2021.

Eluri M, Feneran A, Bordeaux JS. Multiple Merkel cell carcinomas: Late metastasis or multiple primary tumors? A molecular study. JAAD Case Rep. 2017;3(2):131-4.

Paulson KG, Lemos BD, Feng B, et al. Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. J Invest Dermatol. 2009;129(6):1547-55.

Harms KL, Lazo de la Vega L, Hovelson DH. Molecular Profiling of Multiple Primary Merkel Cell Carcinoma to Distinguish Genetically Distinct Tumors From Clonally Related Metastases. JAMA Dermatol. 2017;153(6):505-12.

Cimino PJ, Robirds DH, Tripp SR. Retinoblastoma gene mutations detected by whole exome sequencing of Merkel cell carcinoma. Mod Pathol. 2014;27(8):1073-87.

Starrett GJ, Marcelus C, Cantalupo PG. Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma. mBio. 2017;8(1).

Wang L, Harms PW, Palanisamy N. Age and Gender Associations of Virus Positivity in Merkel Cell Carcinoma Characterized Using a Novel RNA. Clin Cancer Res. 2017;23(18):5622-30.

Paulson KG, Lewis CW, Redman MW. Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study. Cancer. 2017;123(8):1464-74.

Harms KL, Healy MA, Nghiem P. Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System. Ann Surg Oncol. 2016;23(11):3564-71.

Tello TL, Coggshall K, Yom SS. Merkel cell carcinoma: An update and review: Current and future therapy. J Am Acad Dermatol. 2018;78(3):445-54.

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Published

2021-08-23