Comparative study of efficacy of topical minoxidil versus topical minoxidil with finasteride in androgenetic alopecia

Authors

  • Adarsh Gowda Department of Dermatology, Kempegowda Institute of dermatological sciences, Bengaluru, Karnataka, India
  • K. C. Sushmitha Department of Dermatology, Kempegowda Institute of dermatological sciences, Bengaluru, Karnataka, India
  • Krithi Subhash Chandra Department of Dermatology, Kempegowda Institute of dermatological sciences, Bengaluru, Karnataka, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20211448

Keywords:

Androgenetic alopecia, Testosterone, Dihydro testosterone, Male pattern baldness, Topical minoxidil, Topical finasteride

Abstract

Background: Minoxidil and finasteride are most common drugs used in androgenetic alopecia. The objective of the study was to know the efficacy of topical minoxidil solution with and without finasteride.

Methods: In total about 30 subjects, aged 18-45 years, who came for outpatient consultation for male pattern androgenetic alopecia were randomized into two groups. Group A was treated with 0.1% topical finasteride and 5% minoxidil solution and Group B was treated with 5% minoxidil solution after taking informed consent from subjects of both groups.

Results: Analysis of the extent of bald area, hair count and number of terminal hair showed better results in group A compared to group B.

Conclusions: Better results were obtained with combination of topical minoxidil with finasteride than with plain topical minoxidil.

Author Biography

Adarsh Gowda, Department of Dermatology, Kempegowda Institute of dermatological sciences, Bengaluru, Karnataka, India

Associate professor in Department of dermatology, KIMS hospital, Bangalore

References

Arca E, Açıkgöz G, Taştan HB, Köse O, Kurumlu Z. An open, randomized, comparative study of oral finasteride and 5% topical minoxidil in male androgenetic alopecia. Dermatol. 2004;209(2):117-25.

Chandrashekar BS, Nandhini T, Vasanth V, Sriram R, Navale S. Topical minoxidil fortified with finasteride: An account of maintenance of hair density after replacing oral finasteride. Indian dermatol J. 2015;6(1):17.

Moerman DE. The meaning of baldness and implications for treatment. Clin Dermatol. 1988; 6(4):89-92.

Paus R, Cotsarelis G. The biology of hair follicles. New Eng J Med. 1999;341(7):491-7.

Wang TL, Zhou C, Shen YW, Wang XY, Ding XL, Tian S, et al. Prevalence of androgenetic alopecia in China: a community based study in six cities. Br J Dermatol. 2010;162(4):843-7.

Shankar DK, Chakravarthi M, Shilpakar R. Male androgenetic alopecia: population-based study in 1,005 subjects. Int J Trichol. 2009;1(2):131.

Kaliyadan F, Nambiar A, Vijayaraghavan S. Androgenetic alopecia: an update. Indian J Dermatol Venereol Leprol. 2013;79(5):613.

Gupta M, Mysore V. Classifications of patterned hair loss: a review. J Cutan Aesthet Surg. 2016;9(1):3-9.

Hillmer AM, Hanneken S, Ritzmann S, Becker T, Freudenberg J, Brockschmidt FF, et al. Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. Am J Human Gene. 2005; 77(1):140-8.

Dinh QQ, Sinclair R. Female pattern hair loss: current treatment concepts. Clin Intervent Aging. 2007;2(2):189.

Dhurat R. Phototrichogram. Indian J Dermatol Venereol Leprol. 2006;72(3):242.

Norwood OT. Incidence of female androgenetic alopecia (female pattern alopecia). Dermatol Surg. 2001;27(1):53-4.

Gugle AS, Jadhav VM, Kote RP, Deshmukh MD, Dalvi AV. Comparative study of efficacy of topical minoxidil 5% and combination of topical minoxidil 5%, topical azelaic acid 1.5% and topical tretinoin 0.01% on the basis of dermoscopic analysis in androgenetic alopecia. J Med Sci. 2015;2(2):90-9.

Olsen EA, Dunlap FE, Funicella T, Koperski JA, Swinehart JM, Tschen EH, et al. A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol. 2002;47(3):377-85.

Hu R, Xu F, Sheng Y, Qi S, Han Y, Miao Y, et al. Combined treatment with oral finasteride and topical minoxidil in male androgenetic alopecia: a randomized and comparative study in Chinese patients. Dermatol Therapy. 2015;28(5):303-8.

Lee SW, Juhasz M, Mobasher P, Ekelem C, Mesinkovska NA. A systematic review of topical finasteride in the treatment of androgenetic alopecia in men and women. J Drugs Dermatol. 2018; 17(4):457.

Khandpur S, Suman M, Reddy BS. Comparative efficacy of various treatment regimens for androgenetic alopecia in men. J Dermatol. 2002; 29(8):489-98.

Sehgal VN, Kak R, Aggarwal A, Srivastava G, Rajput P. Male pattern androgenetic alopecia in an Indian context: a perspective study. J Eu Acad Dermatol Venereol. 2007;21(4):473-9.

Norwood OT. Male pattern baldness: classification and incidence. Southern Med J. 1975;68(11):1359-65.

Hamilton JB. Patterned loss of hair in man: types and incidence. Ann New York Acad Sci. 1951;53(3):708-28.

Ludwig E. Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. Br J Dermatol. 1977;97(3):247-54.

Downloads

Published

2021-04-27

Issue

Section

Original Research Articles