A comparative study of efficacy of oral itraconazole, terbinafine and fluconazole: a clinical trial

Authors

  • Savita C. Koregol Department of Skin, Al-Ameen Medical College and Hospital, Vijaypur, Karnataka, India
  • Soumya R. Naik Department of Psychiatry, Al-Ameen Medical College and Hospital, Vijaypur, Karnataka, India
  • Abhineetha Hosthota Department of Skin, Oxford Medical College and Hospital, Bengaluru, Karnataka, India
  • Arati C. Koregol Department of Periodontics, PNMN Dental College and Hospital, Bagalkot, Karnataka, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20211705

Keywords:

Itraconazole, Terbinafine, Tinea

Abstract

Background: Keeping in view the rising number of cases of dermatophyte infections and also poor response to topical drugs, this study was conducted with the intention to arrive at a conclusion regarding the best available systemic drug.

Methods: A total of 270 patients were selected for the study. 90 patients were assigned to each group under itraconazole, terbinafine & fluconazole.

Results: It was found that itraconazole was the most effective drug which led to a considerable decrease in erythema, peripheral spread, scaling and spread to other body sites. Next drug to be the most effective was terbinafine, which was followed by fluconazole.

Conclusions: We finally arrived at a conclusion that itraconazole is the most effective drug for all types of superficial fungal infections. It was followed by terbinafine & fluconazole in terms of drug effectiveness. Hence in this study we advocate the use of itraconazole as first line of drug in all patients of tinea infections.

 

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Published

2021-04-27

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Original Research Articles