DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20204560

Prevalence of metabolic syndrome among patients with superficial mycotic infections in a tertiary care hospital

Shamsun N. B. Mannan, Muhammad A. Bakar, Shaikh H. Mamun, Rajat S. R. Biswas, Istiaque Hossain

Abstract


Background: Incidence of metabolic syndrome and superficial mycotic infection is progressively increasing worldwide. Skin disorders, usually neglected and frequently underdiagnosed in patients with metabolic syndrome. So, the objective of the study is to linkup between metabolic syndrome and superficial mycotic infections.

Methods: Total 300 diagnosed patients of superficial mycotic infection out of 1000 patients in a 5 months period from January 2019 to May 2019 who gave consent were chosen at random from the patients attending the OPD consultancy. Thorough clinical evaluation and routine hematological investigations, oral glucose tolerance test (OGTT), fasting lipid profile were tested and BMI and blood pressure were recorded to diagnose metabolic syndrome. Fungal infections were confirmed by KOH mount.

Results: Among 1000 patients attended in OPD consultancy, majority of the patients were female (60%). Among them 300 patients have got different superficial fungal infections (female was 223 and male 77). Among this 300-study population, age variation is significant. There were highest female patients in age group from 36 yrs- 45 yrs. Tinea corporis was the most frequent fungal infection in female (65%), Tinea cruris is highest in male (21%). The most alarming is that among that 300 patients 45% patients have got raised OGTT,91% patient has increased BMI, female predominant. 59.3% has raised blood pressure and increased serum cholesterol in 70.1% patients.  

Conclusions: Superficial fungal infections are epidemic worldwide.  In our study the new era is that presence of metabolic syndrome among patients with superficial mycotic infections. So early detection and treatment of metabolic syndrome helps in cure of superficial mycotic infections.

 


Keywords


Metabolic syndrome, Superficial mycotic infections, Diabetes mellitus

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References


Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5-6):231-7.

Expert Panel on Detection. Evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of The National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). J Americ Medic Assoc. 2001;285(19):2486-97.

Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lanc Lond Engl. 2005;365(9468):1415-28.

Wiley JF, Carrington MJ. A metabolic syndrome severity score: a tool to quantify cardio-metabolic risk factors. Prev Med. 2016;88:189-95.

Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Available at: https://www.ncbi.nlm.nih. gov/pubmed/19805654. Accessed on 18 November 2019.

Cohen JB, Janniger CK, Piela Z, Szepietowski JC, Samady JA, Schwartz RA. Dermatologic correlates of selected metabolic events. J Med. 1999;30(3-4):149-56.

Van Hecke E. Cutaneous manifestations of internal diseases. Acta Clin Belg. 2003;58(5):302-7.

Casqueiro J, Casqueiro J, Alves C. Infections in patients with diabetes mel‑litus: a review of pathogenesis. Ind J Endocrinol Metab. 2012;16(1):S27–36.

Fizelova M, Jauhiainen R, Kangas AJ, Soininen P, Ala‑Korpela M, Kuusisto J, et al. Differential associations of inflammatory markers with insulin sensitivity and secretion: the prospective METSIM study. J Clin Endocrinol Metab. 2017;102(9):3600-9.

Beavers KM, Nicklas BJ. Effects of lifestyle interventions on inflam‑matory markers in the metabolic syndrome. Front Biosci Sch Ed. 2011;1(3):168-77.

Weitzman I, Summerbell RC. The dermatophytes. Clin Microbiol Rev 1995;8:240-59.

Degreef H. Clinical forms of dermatophytosis (ringworm infection). Mycopathologia 2008;166: 257-65.

Svejgaard EL, Nilsson J. Onychomycosis in Denmark: prevalence of fungal infection in general practice. Mycoses. 2004;47:131-5.

Ginter-Hanselmayer G, Weger W, Ilkit M, Smolle J. Epidemiology of tinea capitis in Europe: current state and changing patterns. Mycoses. 2007;50:6-13.

Havlickova B, Czaika VA, Friedrich M. Epidemiological trends in skin mycoses worldwide. Mycos. 2008;51:2-15.

Ameen M. Epidemiology of superficial fungal infections. Clinic Dermatol. 2010;28(2):197-201.

Prasad H, Ryan DA, Celzo MF, Stapleton D. Metabolic syndrome: definition and therapeutic implications. Postgrad Med. 2012;124(1):21-30.

Kaur JA. Comprehensive review on metabolic syndrome. Cardiol Res Prac. 2014;2014;943162.

Bastard JP, Maachi M, van Nhieu JT, Jardel C, Bruckert E, Grimaldi A, et al. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endocrinol Metabol. 2002;87(5):2084-9.

Macedo GM, Nunes S, Barreto T. Skin disorders in diabetes mellitus: an epidemiology and physiopathology review. Diabetol Metabol Syndro. 2016;8(1):63.

Romano G, Moretti G, Di Benedetto A, Giofre C, Di Cesare E, Russo G, et al. Skin lesions in diabetes mellitus: prevalence and clinical correlations. Diabet Res Clin Pract. 1998;39:101-6.

Shahzad M, Al Robaee A, Al Shobaili HA, Alzolibani AA, Al Marshood AA, Al Moteri B. Skin manifestations in diabetic patients attending a diabetic clinic in the Qassim region, Saudi Arabia. Medic Princip Pract. 2011;20(2):137-41.

Mahajan S, Koranne RV, Sharma SK. Cutaneous manifestation of diabetes melitus. Ind J Dermatol Venereol Leprol. 2003;69:105-8.

Nigam PK, Pande S. Pattern of dermatoses in diabetics. Ind J Dermatol Venereol Leprol. 2003;69:83-5-9.

Teklebirhan G, Bitew A. Prevalence of dermatophytic infection and the spectrum of dermatophytes in patients attending a tertiary hospital in Addis Ababa, Ethiopia. Int J Microbiol. 2015;2015.

Adefemi SA, Odeigah LO, Alabi KM. Prevalence of dermatophytosis among primary school children in Oke-oyi community of Kwara state. Niger J Clinic Pract. 2011;14(1)23-8.

Vena GA, Chieco P, Posa F, Garofalo A, Bosco A, Cassano N. Epidemiology of dermatophytoses: retrospective analysis from 2005 to 2010 and comparison with previous data from 1975. Microbiologica Quarterly J Microbiolo Sci. 2012;35(2):207-13.

Havlickova B, Czaika VA, Friedrich M. Epidemiological trends in skin mycoses worldwide. Mycos. 51(4), 2–15.

Popoola TO, Ojo DA, Alabi RO. Prevalence of dermatophytosis in junior secondary schoolchildren in Ogun State, Nigeria. Mycos. 2006;49(6):499-503.

Ameen M. Epidemiology of superficial fungal infections. Clinics in dermatology. 2010;28(2):197-201.

Figueroa JI, Hawranek T, Abraha A, Hay RJ. Tinea capitis in south‐western Ethiopia: a study of risk factors for infection and carriage. Int J Dermatol. 1997;36(9):661-6.

Balakumar S, Rajan S, Thirunalasundari T, Jeeva S. Epidemiology of dermatophytosis in and around Tiruchirapalli, Tamilnadu, India. Asi Pacif J Tropic Dise. 2012;2(4):286-9.

Rassai S, Feily A, Derakhshanmehr F, Sina N. Some epidemiological aspects of dermatophyte infections in Southwest Iran. Acta Dermatovenerologica Croatica. 2011;19(1):13-5.

Romano G, Moretti G, Di Benedetto A, Giofre C, Di Cesare E, Russo G, et al. Skin lesions in diabetes mellitus: prevalence and clinical correlations. Diabet Res Clin Pract. 1998;39:101-6.

Sasmaz S, Buyukbese M, Cetinkaya A, Celik M, Arican O. The prevalence of skin disorders in type-2 diabetic patients. Int J Dermatol. 2004;3(1).

Foss NT, Polon DP, Takada MH, Foss-Freitas MC, Foss MC. Dermatosesempacientes com diabetes mellitus. Saud Pub Revi. 2005;39:677-82.

Wambier CG, Takada MH, Foss-Freitas MC, Frade MAC, Foss MC, Foss NT. Effects of metabolic control on cutaneous findings in diabetes mellitus. Braz J Int Medic. 2014;1:11-9.

Wilson PWF, D’Agostino RB, Parise H, Sullivan L, Meigs JB. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulat. 2005;112(20):3066-72.

Waateringe RP, Slagter SN, Beek AP, Klauw MM, Vliet-Ostaptchouk JV, Graaf R, et al. Skin autofuorescence, a non-invasive biomarker for advanced glycation end products, is associated with the metabolic syndrome and its individual components. Diabetol Metab Syndr. 2017;9:42.