DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20204569

Langerhans cell histiocytosis in an infant: a case report from North-East India

Romita Bachaspatimayum, Kago Yaku

Abstract


Langerhans cell histiocytosis (LCH) is a rare disorder of reticuloendothelial system characterized by uncontrolled proliferation and accumulation of CD1a and CD207 dendritic cells (DCs). 3-4 cases per million occur annually in children under 15 years of age, with a male:female ratio of 2:1 and peak incidence in infants aged 1 to 2 years. Report a case of LCH in a month-old female infant with skin lesions for 2-3 weeks. Skin biopsy was suggestive of LCH and it was confirmed with immunohistochemistry markers that were positive for S100, CD1A and negative for CD68.

 


Keywords


Children, Cutaneous manifestations, LCH

Full Text:

PDF

References


George AE, Yogirajan K. Letterer siwe disease. Indian J Dermatol Venereol Leprol. 2001;67(6):334-35.

Jezierska M, Stefanowicz J, Romanowicz G, Kosiak W, Lange M. Adv Dermatol Allergol. 2018;35(1):6-17.

Rao S, Hegde S, Gopinath Thilak PS, Babu GS, Ajila V, Shetty U et al. Langerhans cell histiocytosis in a 5‑year‑old girl: A case report and review of literature. Indian J Med Paediatr Oncol. 2019;40(5):S176-80.

Shahidi-Dadras M, Saeedi M, Shakoei S, Ayatollahi A. Langerhans cell histiocytosis: An uncommon presentation, successfully treated by thalidomide. Indian J Dermatol Venereol Leprol. 2011;77(5):587-90.

Solanki RB, Shah YB, Shah AN. Langerhans cell histiocytosis. Indian J Dermatol Venereol Leprol. 1995;61(1):42-4.