Skin manifestation of angioimmunoblastic T-cell lymphoma mimicking Hansen’s disease on histology

Authors

  • Anju Shukla Department of Lab Medicine, Sahara Hospital, Lucknow, UP
  • Sunil Sharad Dabadghao Department of Clinical Hematology and Bone Marrow Transplant, Sahara Hospital, Lucknow, UP
  • Surbhi Gupta Department of Lab Medicine, Sahara Hospital, Lucknow, UP
  • Priyanka Jain Department of Lab Medicine, Sahara Hospital, Lucknow, UP

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20202669

Keywords:

Angioimmunoblastic T-cell lymphoma, Cutaneous manifestation, Hansen’s disease

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon form of peripheral T-cell lymphoma now put under the category of nodal T-cell lymphoma with follicular T helper phenotype. 50% cases of AITL have varied cutaneous manifestations including macules, papules, petechiae, purpura, nodules, non-specific rash and urticaria. Herein we present a case of AITL initially presented as maculopapular rash which on histology was mimicking as Hansen’s disease with perineural and perivascular inflammation; however, an infective organism could not be demonstrated. Later on, a delayed diagnosis was made on lymph node biopsy and immunohistochemistry and patient responded well with chemotherapy.

Author Biography

Anju Shukla, Department of Lab Medicine, Sahara Hospital, Lucknow, UP

Senior Consultant

department of Lab Medicine

Sahara Hospital, Viraj Khand, Gomti Nagar, Lucknow

References

Dogan A, Gaulard P, Jaffe ES, Hermelink MHK, Leval DL. Angioimmunoblastic T-cell lymphoma and other nodal lymphomas of T follicular helper cell origin. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al, eds. WHO classification of Tumors of Haematopoietic and Lymphoid Tissues. Revised 4th ed. Lyon: IARC Press; 2017: 408-410.

Rudiger T, Weisenburger DD, Anderson JR, Armitage JO, Diebold J, Lennan MKA, et al. Peripheral T cell lymphoma excluding anaplastic large cell lymphoma: result from the Non-Hogkin’s Lymphoma Classification Project. Ann Oncol. 2002;13:140-9.

Federico M, Rudiger T, Bellei M, Nathwani BN, Luminari S, Coiffier B, et al. Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma Project. J Clin Oncol. 2013;31:240-6.

Brown HA, Macon WR, Kurtin PJ, Gibson LE. Cutaneous involvement in patients with angioimmunoblastic T-cell lymphoma with dysproteinemia: a clinical, immuno histological and molecular analysis. Arch Dermatol. 2000;136:881-6.

Martel P, Laroche L, Courville P, Larroche C, Wechsler J, Lenormand B, et al. Cutaneous involvement in patients with angioimmunoblastic lymphadenopathy with dysproteinemia: a clinical, immuno histological and molecular analysis. Arch Dermatol. 2000;136:881-6.

Bortos N, Cerroni L, Shawwa A, Green P, Greer W, Pasternak S, et al. Cutaneous Manifestations of Angioimmunoblastic T-cell Lymphoma: Clinical and Pathological Characteristics. Am J Dermatopathol. 2015;37:274-83.

Iannitto E, Ferreri AJ, Minardi V, Tripodo C, Kreipe HH. Angioimmunoblastic T-cell lymphoma. Crit Rev Oncol Hematol. 2008;68:264-71.

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Published

2020-06-23

Issue

Section

Case Reports