Skin manifestation of angioimmunoblastic T-cell lymphoma mimicking Hansen’s disease on histology

Anju Shukla, Sunil Sharad Dabadghao, Surbhi Gupta, Priyanka Jain


Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon form of peripheral T-cell lymphoma now put under the category of nodal T-cell lymphoma with follicular T helper phenotype. 50% cases of AITL have varied cutaneous manifestations including macules, papules, petechiae, purpura, nodules, non-specific rash and urticaria. Herein we present a case of AITL initially presented as maculopapular rash which on histology was mimicking as Hansen’s disease with perineural and perivascular inflammation; however, an infective organism could not be demonstrated. Later on, a delayed diagnosis was made on lymph node biopsy and immunohistochemistry and patient responded well with chemotherapy.


Angioimmunoblastic T-cell lymphoma, Cutaneous manifestation, Hansen’s disease

Full Text:



Dogan A, Gaulard P, Jaffe ES, Hermelink MHK, Leval DL. Angioimmunoblastic T-cell lymphoma and other nodal lymphomas of T follicular helper cell origin. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al, eds. WHO classification of Tumors of Haematopoietic and Lymphoid Tissues. Revised 4th ed. Lyon: IARC Press; 2017: 408-410.

Rudiger T, Weisenburger DD, Anderson JR, Armitage JO, Diebold J, Lennan MKA, et al. Peripheral T cell lymphoma excluding anaplastic large cell lymphoma: result from the Non-Hogkin’s Lymphoma Classification Project. Ann Oncol. 2002;13:140-9.

Federico M, Rudiger T, Bellei M, Nathwani BN, Luminari S, Coiffier B, et al. Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma Project. J Clin Oncol. 2013;31:240-6.

Brown HA, Macon WR, Kurtin PJ, Gibson LE. Cutaneous involvement in patients with angioimmunoblastic T-cell lymphoma with dysproteinemia: a clinical, immuno histological and molecular analysis. Arch Dermatol. 2000;136:881-6.

Martel P, Laroche L, Courville P, Larroche C, Wechsler J, Lenormand B, et al. Cutaneous involvement in patients with angioimmunoblastic lymphadenopathy with dysproteinemia: a clinical, immuno histological and molecular analysis. Arch Dermatol. 2000;136:881-6.

Bortos N, Cerroni L, Shawwa A, Green P, Greer W, Pasternak S, et al. Cutaneous Manifestations of Angioimmunoblastic T-cell Lymphoma: Clinical and Pathological Characteristics. Am J Dermatopathol. 2015;37:274-83.

Iannitto E, Ferreri AJ, Minardi V, Tripodo C, Kreipe HH. Angioimmunoblastic T-cell lymphoma. Crit Rev Oncol Hematol. 2008;68:264-71.